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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F1
All Species:
20
Human Site:
Y100
Identified Species:
36.67
UniProt:
Q01094
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01094
NP_005216.1
437
46920
Y100
D
L
E
T
D
H
Q
Y
L
A
E
S
S
G
P
Chimpanzee
Pan troglodytes
XP_524538
437
47536
P97
D
L
E
G
I
G
R
P
V
V
P
E
F
P
T
Rhesus Macaque
Macaca mulatta
XP_001103717
502
53768
Y165
D
L
E
T
D
H
Q
Y
L
A
E
S
S
G
P
Dog
Lupus familis
XP_542963
571
61192
Y235
D
L
E
T
D
H
Q
Y
L
A
E
S
S
G
P
Cat
Felis silvestris
Mouse
Mus musculus
Q61501
430
46305
Y95
D
L
E
T
D
H
Q
Y
L
A
G
S
S
G
P
Rat
Rattus norvegicus
Q62814
300
33206
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515449
468
50133
S90
L
L
D
K
G
S
G
S
D
L
G
S
G
P
R
Chicken
Gallus gallus
Q90977
403
43534
Y77
N
L
E
T
D
H
Q
Y
I
A
E
S
L
P
A
Frog
Xenopus laevis
NP_001090608
426
47125
Y92
D
L
E
T
V
S
R
Y
S
Q
D
G
L
Q
T
Zebra Danio
Brachydanio rerio
NP_001074097
429
46452
Q99
E
L
D
I
T
D
H
Q
Y
S
E
P
A
K
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27368
805
87442
K188
H
H
Q
T
V
Y
Q
K
H
T
A
S
S
A
P
Honey Bee
Apis mellifera
XP_396223
416
46049
G98
N
L
E
M
G
T
T
G
P
S
Q
S
A
F
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123287
404
44387
M74
E
F
D
S
T
K
G
M
R
P
Q
L
G
R
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40.7
86
70.9
N.A.
84.6
23.1
N.A.
39.9
59.9
49.8
37.2
N.A.
20.6
29.7
N.A.
38.4
Protein Similarity:
100
54.4
86.2
72.6
N.A.
88.5
37.9
N.A.
51.2
70
63.3
53.7
N.A.
31.5
46.4
N.A.
54.2
P-Site Identity:
100
20
100
100
N.A.
93.3
0
N.A.
13.3
66.6
33.3
13.3
N.A.
33.3
20
N.A.
6.6
P-Site Similarity:
100
33.3
100
100
N.A.
93.3
0
N.A.
20
80
46.6
40
N.A.
46.6
46.6
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
39
8
0
16
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
0
24
0
39
8
0
0
8
0
8
0
0
0
0
% D
% Glu:
16
0
62
0
0
0
0
0
0
0
39
8
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
8
8
0
% F
% Gly:
0
0
0
8
16
8
16
8
0
0
16
8
16
31
0
% G
% His:
8
8
0
0
0
39
8
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
8
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
0
8
0
8
0
0
0
0
0
8
8
% K
% Leu:
8
77
0
0
0
0
0
0
31
8
0
8
16
0
0
% L
% Met:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
16
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
8
8
8
8
0
24
47
% P
% Gln:
0
0
8
0
0
0
47
8
0
8
16
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
16
0
8
0
0
0
0
8
8
% R
% Ser:
0
0
0
8
0
16
0
8
8
16
0
62
39
0
0
% S
% Thr:
0
0
0
54
16
8
8
0
0
8
0
0
0
0
24
% T
% Val:
0
0
0
0
16
0
0
0
8
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
47
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _